If you’re using Ozempic for weight loss or blood sugar control and suddenly find yourself thinking, “Why am I so tired all the time?”—you’re not alone. Many people also report that they tend to feel tired, especially during the first few weeks. A frustrating energy crash is a common experience while taking this popular diabetes medication. Fatigue, sluggishness, and even brain fog are among the most common side effects of Ozempic—but the good news is, they can often be addressed with the right support.

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Using Ozempic for weight management might help shed pounds, but it can also leave your body undernourished if you’re not getting enough essential nutrients. A quality multivitamin helps fill those nutritional voids, maintaining energy and muscle mass.

One reason fatigue may creep in? A lack of essential nutrients like Vitamin B12, which plays a major role in how your body creates and uses energy. In fact, understanding how Vitamin B12 affects energy levels can help you uncover what’s really going on behind your Ozempic exhaustion.

Ozempic (semaglutide) belongs to a class of drugs called GLP-1 receptor agonists, originally designed to help people with Type 2 diabetes control their blood sugar levels. Ozempic shares the same active ingredient, semaglutide, with other medications like Wegovy, but their specific uses and dosages differ. Its ability to reduce appetite and support weight loss has made it a go-to for weight management too. The trade-off? Some users feel like their energy levels flatline—especially during dosage changes or when their calorie intake drops too quickly.

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This article breaks down why fatigue happens on Ozempic, how it affects your metabolic processes, and how smart nutrition strategies—like using a high-quality multivitamin—can help you feel energized, clear-headed, and strong while still reaching your goals.

How Ozempic Works—and Why It Can Leave You Feeling Tired

Ozempic, also known by its generic name semaglutide, is a medication primarily used to treat type 2 diabetes and support weight loss. It works by mimicking the hormone GLP-1, which plays a crucial role in regulating blood sugar levels. GLP-1 stimulates the release of insulin, a hormone that helps lower blood sugar, and suppresses the release of glucagon, which raises blood sugar. This dual action helps maintain more stable blood glucose levels.

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In addition to its effects on blood sugar, Ozempic also reduces appetite by slowing down the digestive process. This leads to decreased calorie intake, which is beneficial for weight loss. However, this sudden reduction in calories can sometimes result in fatigue, alongside other side effects such as vomiting, as your body adjusts to the new energy levels. Essentially, your body is learning to operate on fewer calories, which can temporarily make you feel more tired than usual.

‎Ozempic Fatigue: A Common Side Effect

Fatigue is a common side effect experienced by many Ozempic users, with up to 11% of participants in clinical trials reporting this issue. The exact cause of Ozempic fatigue isn’t entirely understood, and it may be linked to other common side effects experienced by users—but it is believed to be linked to the rapid changes in blood sugar levels and the significant decrease in calorie intake.

As your body adjusts to these changes, you may feel more tired than usual. One likely contributor? Low levels of essential nutrients like B12. In fact, understanding how Vitamin B12 affects energy levels can help you better manage that sluggish feeling and get ahead of the crash.

The good news is that this fatigue often improves over time as your body gets used to the medication. However, it’s crucial to address this fatigue to maintain your overall health and well-being. Ignoring it can lead to a decrease in your quality of life and make it harder to stick with your treatment plan.

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Why Ozempic Can Leave You Feeling Drained: Understanding Ozempic Fatigue

To understand why you might feel like you’ve hit a wall after starting Ozempic, it helps to know what’s happening behind the scenes in your body. Ozempic works by mimicking a hormone called GLP-1, which slows down your digestive system, reduces appetite, and improves insulin sensitivity. While that’s great for blood sugar control and weight loss, it also throws your energy regulation into temporary chaos.

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Here’s the thing: when your calorie intake suddenly decreases—as it often does when taking Ozempic—your body starts conserving energy. That’s a natural response, but it can make you feel sluggish, unfocused, and more prone to fatigue. Combine that with the side effects of Ozempic like nausea, diarrhea, and an upset stomach, and it’s no wonder some people feel completely wiped out.

Some users may also experience injection site reactions, such as discomfort or redness. For those seeking easier absorption without injections, a sublingual multivitamin powder may be a beneficial alternative during this adjustment period.

These symptoms often get worse during the first few weeks, especially while your dose is increasing. Your body is adjusting to the new rhythm, and if concerns arise, consulting your healthcare provider can be beneficial during this transition period.

The good news? These dips in energy are usually temporary. Once your body adjusts, most people find that their symptoms improve. But that adjustment period can be rough—especially if your diet isn’t keeping up with your body's needs.

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Decreased Calorie Intake = Decreased Nutrient Intake

One of the main ways Ozempic helps with weight loss is by making you feel full faster and for longer. It reduces appetite, slows gastric emptying, and often leads to a sharp decrease in calorie intake. While that sounds like a win for the scale, there’s a hidden downside: fewer calories can also mean fewer nutrients—making it harder to fill nutritional gaps that your body depends on for energy and recovery.

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This lack of nutrients can sneak up on you. When your meals shrink in size or frequency, you risk falling short on key vitamins and minerals that support your energy and are crucial for maintaining muscle mass. And when your digestive system slows down, your ability to absorb what you do eat may also be impacted.

One of the biggest risks here? Muscle loss. As your body sheds weight, it may break down both fat and muscle if it’s not getting enough protein and essential nutrients. That can leave you feeling even more tired, weak, or foggy—especially if you’re not supplementing properly.

This is where the right nutrition strategy becomes essential. And no, that doesn’t mean eating more—it means eating smart.

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The Underrated Role of Vitamin B12 & Other Vital Nutrients

If you’re dealing with Ozempic fatigue, one of the first places to look is your Vitamin B12 levels. This powerhouse nutrient plays a key role in maintaining energy levels, supporting red blood cell production, and helping your body absorb nutrients efficiently so it can convert food into usable fuel. When you're in a calorie deficit, not only are you likely consuming less B12—but your body may also be absorbing less due to slower gastric emptying, a common side effect of Ozempic.

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And B12 isn’t the only concern. A reduced appetite or upset stomach can make it hard to get enough nutrients like magnesium, potassium, folate, and iron—each essential for avoiding fatigue, maintaining focus, and preventing muscle loss. That’s why doctors often recommend adding a multivitamin to support your body’s metabolism, especially during periods of weight loss or dietary restriction, as supported by a meta-analysis of nutrient absorption studies.

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Enter: Sport Formula 99 Multivitamin Powder

To bridge those gaps, many turn to Sport Formula 99 Multivitamin Powder, a high-quality, cold-processed and raw multivitamin powder designed to deliver fast, effective nutrition without upsetting your stomach. It contains safe and powerful energy-supporting ingredients like:

• Vitamin B12 for fatigue support
  
  
• Amino acids to help preserve muscle mass
  
  
• Electrolytes for hydration and nerve function
  
  
• Antioxidants to support overall health
  

Because it’s a powdered multivitamin, it bypasses the slowed digestion many experience with GLP-1 medications—making it a convenient way to keep your energy up even when your appetite is down. You can take it sublingually or mix it with water, smoothies, or even pre-workout drinks. It’s also ideal for people who struggle with pill swallowing or don’t feel like eating while adjusting to this new medication.

If your energy levels have taken a dive, or you’re constantly asking, “Why does Ozempic cause fatigue?”—this is a proven strategy worth exploring.

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Managing Blood Sugar and Fatigue

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Low Blood Sugar and Fatigue

One of the potential side effects of taking Ozempic, especially when combined with other diabetes medications, is low blood sugar, also known as hypoglycemia. Symptoms of hypoglycemia include fatigue, shakiness, sweating, dizziness, and confusion. These symptoms can be particularly challenging when you’re already dealing with the fatigue associated with Ozempic.

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To manage low blood sugar and the associated fatigue, it’s essential to monitor your blood glucose levels regularly. This allows you to make necessary adjustments to your medication dosages and dietary intake. Eating small, frequent meals can help keep your blood sugar levels stable, reducing the risk of hypoglycemia and its tiring effects.

Incorporating foods rich in vital nutrients such as fruits, vegetables, and whole grains can also help alleviate fatigue. These foods provide essential vitamins and minerals that support overall health and energy levels. Additionally, avoiding high-fat foods and choosing low sugar options can help manage digestive system side effects like upset stomach and abdominal pain, which can further contribute to fatigue.

Staying hydrated is another crucial factor in managing fatigue. Dehydration can exacerbate feelings of tiredness, so make sure to drink plenty of water throughout the day. Regular exercise and adequate protein intake are also essential for maintaining muscle mass and overall health, which can help combat fatigue and support weight management.

By understanding how Ozempic affects your body and taking proactive steps to manage your blood sugar levels, stay hydrated, and maintain a balanced diet, you can reduce fatigue and improve your overall health and well-being.

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Hydration, Sleep, and Bowel Regimen: Small Fixes, Big Gains

It’s easy to overlook the basics when you're focused on managing Ozempic side effects, but simple changes like drinking more water, getting enough sleep, and maintaining a consistent bowel regimen can dramatically improve how you feel on this medication.

Stay Hydrated

One of the best ways to fight Ozempic fatigue? Drink plenty of water daily. Dehydration can sneak up fast, especially when you're eating less or experiencing gastrointestinal side effects like nausea, vomiting, or diarrhea. Staying hydrated helps regulate blood sugar levels, aids digestion, and keeps your energy more stable throughout the day. Many users find that incorporating a multivitamin powder with zero sugar nutrition makes it easier to stay consistent while also supporting energy and hydration.

Improve Sleep Quality

Getting quality sleep is another underestimated weapon against tiredness. Sleep quality directly impacts your body's ability to recover, balance hormones, and maintain proper metabolic processes. If you're feeling extra tired after starting Ozempic, improving your sleep schedule could help your body adjust more smoothly. Supporting recovery with the right nutrients may also help you get the most from your all-in-one multivitamin powder, especially when taken consistently before bed or after meals.

Keep Things Moving

Finally, let’s talk digestion. GLP-1 medications like Ozempic are known for slowing down the digestive system, which can cause constipation and discomfort. A good bowel regimen—including fiber, water, and possibly a gentle stool softener—can help your body feel more balanced and energized. It might sound minor, but regularity can make a big difference when it comes to fighting that all-too-common Ozempic-related fatigue. Multivitamins that support gut health may help keep things moving and improve nutrient absorption.

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Exercise: Counterintuitive, but Crucial

When you’re already feeling wiped out, the last thing you probably want to do is lace up your shoes and move. But here’s the thing—getting in some regular exercise could be one of the most effective ways to fight Ozempic-related fatigue and stabilize your energy levels.

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Low-impact movement like walking, yoga, or light resistance training helps wake up your metabolic processes, improve insulin sensitivity, and preserve lean muscle mass—a critical factor when you’re losing weight. Muscle loss is a real concern on a calorie deficit, especially if you’re not consuming enough protein or supporting your body with vital nutrients.

And there’s a mental bonus: physical activity releases endorphins, boosts mood, and improves sleep quality—all of which play a role in your overall health and ability to stay energized.

Even if it feels like a stretch at first, try to build activity into your day in small ways. A short walk after meals. Light stretching before bed. Over time, it adds up—and can help prevent the tiredness and brain fog that sometimes follow when taking Ozempic.

If your fatigue has you feeling stuck, movement might be the missing ingredient your body needs to bounce back.

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Adjusting to the Medication: What to Expect in the First 6 Weeks

If you’ve just started taking Ozempic and feel like you’re running on empty, you’re not imagining it. For many users, Ozempic fatigue hits hardest during the first few weeks—especially as the dose increases and the body adjusts to this powerful new medication.

While adjusting to Ozempic, it's important to be aware of serious side effects related to the drug, like difficulty breathing, which require immediate medical attention.

This is a normal phase known as the adjustment period, and while it can be uncomfortable, it’s often temporary. The side effects of Ozempic, like nausea, diarrhea, and a general sense of being “off,” tend to be most intense during the first 2 to 6 weeks. Your body is recalibrating everything from blood sugar levels to digestion, and that can zap your energy.

During this phase, it’s more important than ever to:

• Stay hydrated
• Prioritize sleep quality
• Use a multivitamin cold-processed multivitamin powder for maximum absorption to support energy levels and nutrient intake
• Avoid high-fat foods that worsen gastrointestinal side effects

Many people also find that their tiredness improves significantly once their dose stabilizes and their body adjusts. That’s why this stage is a great time to implement strategies like adding Sport Formula 99 all-in-one vitamin powder, getting regular exercise, and being extra mindful about nutrition.

Think of it as the onboarding period for your metabolism—challenging, yes, but manageable with the right support.

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Final Thoughts: Supporting Your Body While Using Ozempic

Using Ozempic can be a game-changer for managing blood sugar and achieving long-term weight loss—but if you're feeling drained, it’s your body's way of asking for extra support.

Whether it's the result of a calorie deficit, low nutrient intake, or your digestive system adjusting to a new medication, one thing is clear: ignoring fatigue only makes things harder. The good news? You don’t have to just “push through it.”

With a smart combination of:

• Hydration
  
  
• Quality sleep
  
  
• Regular exercise and recovery
  
  
• A consistent bowel regimen
  
  
• And a powerful, cold-processed and raw multivitamin powder like Sport Formula 99
  

—you can give your body exactly what it needs to stay strong, energized, and focused.

Sport Formula 99 offers a convenient way to bridge nutritional gaps created by Ozempic-related fatigue. With Vitamin B12, amino acids, electrolytes, and other vital nutrients, it helps combat tiredness, preserve muscle mass, and support metabolic health—without leading to issues like abdominal pain.

Remember, the goal isn’t just to lose weight—it’s to feel your best while doing it. If Ozempic fatigue has been slowing you down, now’s the time to take control of your energy, your health, and your journey forward.

Ready to transform your health and experience the benefits of the best multivitamin powder on the market?

Join the community of Sport Formula 99 users and take the first step toward a healthier, more energized you.